NoticiasMoBioFood

Miércoles, 1 de marzo de 2017

Recently published paper in the journal Molecular Nutrition and Food Research

Our work entitled "Chronic supplementation with dietary proanthocyanidins protects from diet-induced intestinal alterations in obese rats" authored by Gil-Cardoso, Katherine, Ginés Iris^, Pinent Montserrat, Ardévol Anna, Arola Lluís, Blay Mayte and Terra Ximena has just been published in the Molecular Nutrition and Food Research.

The present study investigated in obese rats the role of grape seed proanthocyanidin extract (GSPE) chronic treatment, taken in a low, moderate or high dose, on obesity-associated intestinal alterations in response to a cafeteria diet. GSPE decreased the ROS levels and MPO activity, without substantial differences among the doses. The supplementation with moderate and high GSPE doses significantly decreased iNOS expression compared to the CAF group, and the same pattern was observed in the low dose animals with respect to IL-1β expression. Moreover, the results show that GSPE significantly increases ZO-1 expression with respect to the CAF animals.

Martes, 14 de febrero de 2017

Carlos A. González obtained a grant from the catalan government. Congratulations!!!

Miércoles, 8 de febrero de 2017

MoBioFood welcomes Marieke! A new member of the research group

Marieke is a Master student from the Technische Universitat Darmstadt (Germany) and she is going to stay with us until the end of June. During her stay she will improve her skills on biochemistry and molecular biology techniques.

Lunes, 6 de febrero de 2017

New paper published in the British Journal of Nutrition

Our work entitled "A cafeteria diet triggers intestinal inflammation and oxidative stress in obese rats" authored by Gil-Cardoso K, Ginés I, Pinent M, Ardévol A, Terra X, Blay M has just been published in the British Journal of Nutrition.

In this study we describe the impact of an obesogenic diet on the gut health status of DIO rats in comparison with the Zucker (fa/fa) rat leptin receptor-deficient model of genetic obesity over time. Our results indicated that both the nutritional model and the genetic obesity model showed increased body weight and metabolic alterations at the final time point. An increase in intestinal ROS production and MPO activity was observed in the gastrointestinal tracts of rats fed a CAF diet but not in the genetic obesity model. TNF-α was overexpressed in the ileum of both CAF diet and fa/fa groups, and ileal inflammation was associated with the degree of obesity and metabolic alterations. We concluded that, in the hyperlipidic refined sugar diet model of obesity, the responses to chronic energy overload led to time-dependent increases in gut inflammation and oxidative stress.

Lunes, 9 de enero de 2017