Displaying from 1 to 3 of 3 available piece of news with tag "GSPE"
Our work entitled "Chronic supplementation with dietary proanthocyanidins protects from diet-induced intestinal alterations in obese rats" authored by Gil-Cardoso, Katherine, Ginés Iris, Pinent Montserrat, Ardévol Anna, Arola Lluís, Blay Mayte and Terra Ximena has just been published in the Molecular Nutrition and Food Research.
The present study investigated in obese rats the role of grape seed proanthocyanidin extract (GSPE) chronic treatment, taken in a low, moderate or high dose, on obesity-associated intestinal alterations in response to a cafeteria diet. GSPE decreased the ROS levels and MPO activity, without substantial differences among the doses. The supplementation with moderate and high GSPE doses significantly decreased iNOS expression compared to the CAF group, and the same pattern was observed in the low dose animals with respect to IL-1β expression. Moreover, the results show that GSPE significantly increases ZO-1 expression with respect to the CAF animals.
Our main aim in this work was to define the most effective satiating doses of GSPE that could be used to reduce body weight gain.